Synthetic bone replacement material NanoBone®
NanoBone® is a biomimetic material because it is modelled on natural processes and uses them to build bone.
The structure of the bone regeneration material is very similar to that of natural bone. By combining nanocrystalline hydroxyapatite (HA), which is also the main component of autologous bone, and nanostructured silica gel, which actively supports bone formation, bone is built up through a completely natural process - remodelling.
The nanocrystalline hydroxyapatite in NanoBone® has the same morphology as in autologous bone. Due to the low production temperatures, the HA remains unsintered.
The silicon in the silica gel is an essential trace element that promotes healthy hair, nails, skin and bones. At the same time, silicon is the main element of bone-forming cells and is responsible for the structure and stability of bone.
Synthetic material for bone formation - properties and advantages of NanoBone®:
The synthetic bone regeneration material
NanoBone® is free from animal and human components and therefore free from any risk of material-related contamination. Ethical concerns can be ruled out during patient counselling. The high-tech production processes ensure consistent product quality.
Complete remodelling
Due to its special structure, NanoBone® utilises natural remodelling. Osteoclasts break down the material to the same extent that osteoblasts form new bone. Material degradation and bone formation are therefore linked. This leads to predictable results and a reliable bone bed.
Controlled osteoinduction
NanoBone® is osteoconductive and osteoinductive. It therefore not only serves as a guiding scaffold, but also actively promotes the formation of new bone.
Biologisation through NanoBone® - natural bone through remodelling
Augmentation with NanoBone®
The NanoBone® Technology offers indication-specific products according to the clinical situation:
- NanoBone® | granules fine and coarse
- NanoBone® | block
- NanoBone® QD
Pure time saving through quick and easy handling.
Extremely large inner surface for protein adhesion
Due to their special structure, all NanoBone® Products have an extremely large inner surface area. This is crucial for protein adhesion and therefore for rapid regeneration.
Matrix change - biologisation and angiogenesis
The matrix change results in biologisation of the material - after a few days the silica gel is replaced by an organic matrix without any loss of volume.
Important proteins for regeneration, such as osteopontin and osteocalcin, as well as BMP-2 are now detectable*
The nanostructure also leads to rapid angiogenic development. This is the prerequisite for very rapid new bone formation.
Natural remodelling
Due to the special structure of NanoBone® the body recognises the material as endogenous.
For this reason, NanoBone® is completely remodelled into autologous bone by osteoclasts and osteoblasts as part of natural remodelling. No foreign substances remain that could disrupt the natural biomechanics.
Implant placement
Depending on the indication, the implant can be inserted after 3 - 6 months.
- after approx. 10 days: matrix change
- from 3 months: Implant placement after external Sinuslift**
- from 4-6 months: Extraction socket/socket preservation
- from 6-9 months: lateral ridge widening/ block augmentation
- after approx. 12 months: NanoBone® completely biodegraded=completely autologous bone
** Meier et al: Use of the synthetic nanostructured bone augmentation material NanoBone in sinus bone augmentation. Implantologie 2008;16(3):301-314
Complete remodelling
As part of the remodelling process, NanoBone® is completely remodelled into autologous bone within 12 - 14 months.***
No foreign substances that could disrupt the natural biomechanics remain, only natural bone, which is the best implant site.
*** Götz et al: Immunohistochemical characterisation of nanocrystalline hydrxyapatite silica gel (Nano- Bone) osteogenesis: A study on biopsies from human jaws. Clin Oral Implants Res 2008;19(10):1016-1026
